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NU6300

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Catalog No. T16360Cas No. 2070015-09-5

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

NU6300

NU6300

😃Good
Catalog No. T16360Cas No. 2070015-09-5
NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.
Pack SizePriceAvailabilityQuantity
5 mg1.016 €8-10 weeks
25 mg1.729 €8-10 weeks
50 mg2.261 €8-10 weeks
100 mg2.945 €8-10 weeks
1 mL x 10 mM (in DMSO)1.119 €8-10 weeks
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Product Introduction

Bioactivity
Description
NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.
Targets&IC50
CDK2:0.16 μM
In vitro
NU6300 blocks the inhibitor binding site. The effect was time-dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr. NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition.
Chemical Properties
Molecular Weight413.49
FormulaC20H23N5O3S
Cas No.2070015-09-5
Relative Density.1.344 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 32 mg/mL (77.39 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4184 mL12.0922 mL24.1844 mL120.9219 mL
5 mM0.4837 mL2.4184 mL4.8369 mL24.1844 mL
10 mM0.2418 mL1.2092 mL2.4184 mL12.0922 mL
20 mM0.1209 mL0.6046 mL1.2092 mL6.0461 mL
50 mM0.0484 mL0.2418 mL0.4837 mL2.4184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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