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RMC-6291

RMC-6291
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RMC-6291

Catalog No. T75131Cas No. 2641998-63-0
RMC-6291 is an orally available, highly potent KRASG12C(ON) inhibitor with anticancer and antitumor activity that acts through spatial blockade of RAS effector binding.RMC-6291 blocks ERK signaling and induces apoptosis in KRASG12C-mutant H358 cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$162In Stock
2 mg$238In Stock
5 mg$392In Stock
10 mg$668In Stock
25 mg$1,180In Stock
50 mg$1,980In Stock
100 mg$3,230In Stock
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Product Introduction

Bioactivity
Description
RMC-6291 is an orally available, highly potent KRASG12C(ON) inhibitor with anticancer and antitumor activity that acts through spatial blockade of RAS effector binding.RMC-6291 blocks ERK signaling and induces apoptosis in KRASG12C-mutant H358 cells.
In vivo
RMC-6291 (200mg/kg, orally, once daily, for 60 days) significantly inhibits tumor growth and induces immune memory in mouse tumor models. [1]
AliasRMC 6291, RMC6291
Chemical Properties
Molecular Weight1012.26
FormulaC55H78FN9O8
Cas No.2641998-63-0
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: DMSO: 80 mg/mL (79.03 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9879 mL4.9394 mL9.8789 mL49.3944 mL
5 mM0.1976 mL0.9879 mL1.9758 mL9.8789 mL
10 mM0.0988 mL0.4939 mL0.9879 mL4.9394 mL
20 mM0.0494 mL0.2470 mL0.4939 mL2.4697 mL
50 mM0.0198 mL0.0988 mL0.1976 mL0.9879 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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