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ANT3310

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Purity:99.51%

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COA LCMS HNMR

ANT3310

Catalog No. T60050Cas No. 2410688-61-6

ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$133	In Stock
25 mg	$283	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description	ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.
In vitro	ANT3310 shows a low in vitro cytotoxicity (IC50 > 100 μM), cardiotoxicity (inhibition of the hERG potassium ion channel) and genotoxicity in HepG2 cell. ANT3310 (0.006 to 3 000 nM) inhibits a series of Serine β-Lactamase including AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2, with IC<>50 values ranging from 1 nM to 175 nM[1].
In vivo	In male Swiss albino mice, ANT3310 (1 mg/kg; i.v.) shows a T1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg. In the murine thigh infection model, ANT3310 (25, 50 and 100 mg/kg; i.v.) reduces bacterial burdens in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM[1].

Chemical Properties

Molecular Weight	262.19
Formula	C6H8FN2NaO5S
Cas No.	2410688-61-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (190.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8140 mL	19.0701 mL	38.1403 mL	190.7014 mL
5 mM	0.7628 mL	3.8140 mL	7.6281 mL	38.1403 mL
10 mM	0.3814 mL	1.9070 mL	3.8140 mL	19.0701 mL
20 mM	0.1907 mL	0.9535 mL	1.9070 mL	9.5351 mL
50 mM	0.0763 mL	0.3814 mL	0.7628 mL	3.8140 mL
100 mM	0.0381 mL	0.1907 mL	0.3814 mL	1.9070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc