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TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1]. |
Targets&IC50 | TAED2:179 nM, TAED1:14 nM, TAED3:4 nM |
In vitro | TEAD-IN-10 demonstrated potent inhibitory effects in the MCF-7 reporter gene assay (IC 50 ≤10 nM) [1]. This compound exhibits excellent selectivity for TEAD1 and TEAD2 with inhibition rates in HEK293T cells of 97% and 98%, respectively [1]. In cell viability assays, TEAD-IN-10 showed better inhibition in H2052 cells (IC 50 ≤100 nM) compared to NCl-H226 cells (IC 50: 100-500 nM) [1]. Furthermore, cell proliferation assays revealed that anti-proliferative inhibition rates exceeded 75% in both NCl-H226 and H2052 cell lines [1]. |
Molecular Weight | 281.27 |
Formula | C15H14F3NO |
Cas No. | 3032196-65-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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