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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
2 mg | $46 | In Stock | |
5 mg | $76 | In Stock | |
10 mg | $126 | In Stock | |
25 mg | $259 | In Stock | |
50 mg | $417 | In Stock | |
100 mg | $622 | In Stock | |
1 mL x 10 mM (in DMSO) | $84 | In Stock |
Description | Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo. |
In vitro | Sulfopin (2μM, HEK293 cells, 48 hours) downregulates Myc transcription. Sulfopin (1μM, 2.5μM, PATU-8988T cells, 4 days) shows a significant reduction in the member of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells.[1] |
In vivo | Sulfopin (40mg/kg, p.o., bis in die/qualer in die for 7 days) regresses neuroblastoma in mice. Sulfopin (20-40mg/kg, i.p., daily for days) inhibits pancreatic cancer progression in mice.[1] |
Alias | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- |
Molecular Weight | 281.8 |
Formula | C11H20ClNO3S |
Cas No. | 2451481-08-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (319.38 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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