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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP1137L | Pancreatic Polypeptide (human) acetate | Neuropeptide Y Receptor | |
Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist. | |||
TP1044L | Pancreatic Polypeptide, rat acetate | Neuropeptide Y Receptor | |
Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4. | |||
TP1044 | Pancreatic Polypeptide, rat | Rat pancreatic polypeptide | |
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is ... | |||
TP1137 | Pancreatic Polypeptide, human | Human pancreatic polypeptide | |
Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract. | |||
T0517 | Pancreatin | Pancreatic enzymes,pancrelipase | Others |
Pancreatin (pancrelipase) is a mixture of several digestive enzymes secreted by the exocrine cells of the pancreas. It is composed of amylase, lipase and protease. | |||
TP1731 | Pancreatic Polypeptide, bovine | ||
Agonist at Y4 neuropeptide Y receptors. | |||
T3359 | Aprotinin | Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin | Others , Serine Protease , Influenza Virus , Proteasome |
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat... | |||
T76538 | Pancreatic polypeptide | ||
Pancreatic polypeptide, a peptide produced by the pancreas's endocrine PP cells, modulates pancreatic secretory functions and influences hepatic glycogen levels and gastrointestinal secretion [1]. | |||
T63015 | Pancreatic lipase/Carboxylesterase 1-IN-1 | ||
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent, dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A), acting on PL (IC50: 2.13 μM) and hCES1A (IC50: 0.055 μM). | |||
T8439 | Clobenpropit dihydrobromide | Apoptosis , Histamine Receptor | |
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07) | |||
T9693 | TBAP-001 | Raf | |
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay. | |||
T5469 | K-Ras-IN-1 | Raf , Ras | |
K-Ras-IN-1 is a K-Ras inhibitor. | |||
T8982 | RH01687 | Others | |
RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. | |||
T9050 | AG-270 | Others , Methionine Adenosyltransferase (MAT) | |
AG-270 is an allosteric and orally active inhibitor of MAT2A. | |||
T10255 | AES-135 | HDAC | |
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity. | |||
T21773 | SP-141 | SP 141 | Mdm2 |
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T4367 | Mycro 3 | Mycro-3 | c-Myc , Autophagy |
Mycro 3 is potent and selective for c-Myc in whole cell assays. | |||
T2055 | WS3 | EGFR , IκB/IKK | |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
T60028 | MM41 | DNA/RNA Synthesis | |
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line. | |||
T9593 | Senaparib | IMP4297 | PARP |
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity. | |||
T14779 | BRD7389 | SGK , FLT , Pim , CDK , S6 Kinase , DAPK | |
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. | |||
T15159 | Dorzagliatin | HMS5552 | Glucokinase |
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. | |||
T8901 | YUM70 | Apoptosis , GPR , HSP | |
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate... | |||
T2058 | Palosuran | ACT-058362 | GPR |
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor. | |||
T3283 | Cetilistat | ATL-962 | Lipid |
Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes. | |||
T11282 | FGTI-2734 | Transferase | |
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat... | |||
T12006 | Metarrestin | ML246 | DNA/RNA Synthesis |
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (... | |||
T9465 | ZZW-115 hydrochloride | Apoptosis , Others | |
ZZW-115 hydrochloride inhibits the activity of NUPR1. | |||
T2667 | PIK-75 | Apoptosis , DNA-PK , PI3K | |
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM). | |||
T6916 | OICR-9429 | OICR 9429 | Histone Methyltransferase , JAK |
OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro. | |||
T15017 | CU-T12-9 | TLR | |
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat... | |||
T7539 | O6-Benzylguanine | Apoptosis , DNA Alkylation , DNA/RNA Synthesis | |
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. | |||
T2148 | Carbidopa monohydrate | Carbidopa Hydrate,S(-)-Carbidopa | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. | |||
T0686 | Orlistat | Ro-18-0647,Tetrahydrolipstatin | Apoptosis , Others , Fatty Acid Synthase |
Orlistat (Tetrahydrolipstatin) is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor. | |||
T9240 | Sulfopin | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- | Others |
Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo. | |||
T8766 | GOT1 inhibitor-1 | GOT1 inhibitor 2c | Others |
GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. | |||
T12883 | Fezagepras | PBI-4050,Setogepram | GPR |
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. | |||
T9831 | MKC-1 | Ro-31-7453 | Apoptosis , Akt , Microtubule Associated , mTOR |
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format... | |||
T28475 | Pyrazoloacridine | PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 | Apoptosis , Topoisomerase |
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. | |||
T1603 | Glipizide | CP 28720,K 4024 | Potassium Channel , PPAR , ABC |
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. | |||
T2275 | YK-4-279 | Apoptosis , DNA/RNA Synthesis | |
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1. | |||
T15389L | Glucagon (1-29), bovine, human, porcine hydrochloride | Porcine glucagon hydrochloride,Glucagon hydrochloride | Glucocorticoid Receptor , Glucagon Receptor |
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon (1-29), bovine, human, porcine hydrochloride(Po... | |||
TQ0157 | EIPA | L593754,MH 12-43 | Sodium Channel , TRP/TRPV Channel |
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | |||
T6823 | E3330 | HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis | |
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. | |||
T2287 | PIK-75 hydrochloride | PIK-75 HCl,PIK-75 | Apoptosis , DNA-PK , PI3K |
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays. | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T75913 | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA | ||
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent, selective neuropeptide Y Y5 receptor agonist, demonstrating binding affinity with an IC50 of 0.24 nM for the hY5 receptor. This compound significan... | |||
TP1963 | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide | cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide | |
Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM)... | |||
T77679 | HPL-IN-2 | Others | |
hPL-IN-2 is a potent, reversible and non-competitive inhibitor of Pancreatic lipase (IC50: 1.63 μM) that can be used to investigate obesity-related diseases. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5S0777 | Phellodendrine chloride | Others | |
Phellodendrine chloride has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
TN2269 | Tetramethylcurcumin | Apoptosis , STAT | |
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e... | |||
T6795 | Carbidopa | (S)-(-)-Carbidopa,Lodosyn | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. | |||
T4964 | Steviolbioside | CCRIS-6025 | Others |
Steviolbioside (CCRIS-6025) is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside(CC... | |||
T1511 | Daunorubicin hydrochloride | Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin | Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis. | |||
T4S1312 | Gypsogenin-3-O-glucuronide | Methyl gypsogenin 3-O-beta-D-glucuronopy | Others |
1. Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) shows inhibitory activity toward pancreatic lipase with IC5 value of .29 mM, and the free carboxylic acid groups in position 28 within its chemical... | |||
TN1620 | Eriocalyxin B | Apoptosis , cAMP , NF-κB , STAT | |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh... | |||
T14840 | Butyrylcarnitine | Endogenous Metabolite | |
Butyrylcarnitine is a plasma metabolite that is an indicator of abnormal metabolism due to disease and is used in the diagnosis of heart failure and pancreatic cysts. | |||
T6942 | Picolinamide | 2-Pyridinecarboxamide,2-Carbamoylpyridine,2-Picolinamide,Picolinoylamide | PARP |
Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. | |||
T36115 | Colchicoside | 3-Demethylcolchicine glucoside | Others |
Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma. | |||
T5668 | Triacetylresveratrol | Acetyl-trans-resveratrol | BCL , NF-κB , STAT |
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells. | |||
T5707 | 3-O-Methylgalangin | 3-Methylgalangin,GALANGIN-3-METHYLETHER | Antibacterial |
3-O-Methylgalangin (GALANGIN-3-METHYLETHER) has antibacterial activity, it has inhibitory effects on Pseudomonas aeruginosa. GALANGIN-3-METHYLETHER has hypolipidemic activity, the action is due to the inhibition of pancr... | |||
T0743 | DL-Carnitine | Carnitina,Carnitine | Others |
DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias. | |||
T2840 | Phloracetophenone | 2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone | Others , P450 , Antibacterial , Antibiotic |
Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity. | |||
T20604L | Litorin acetate(55749-97-8 Free base) | Bombesin Receptor | |
Litorin acetate, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. It stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the n... | |||
T2203 | D-Carnitine hydrochloride | (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride | Others , Endogenous Metabolite |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) is a constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemi... | |||
T3028 | Tripterin | Celastrol,Tripterine | Apoptosis , Mitophagy , Proteasome , Autophagy |
Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula... | |||
T10086 | 24-Hydroxycholesterol | Cholest-5-ene-3beta,24-diol | Liver X Receptor , NMDAR |
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcription factor LXR, which has been used in the study of cardioge... | |||
T2P2919 | (2S,3R,4S)-4-Hydroxyisoleucine | (4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine | PI3K |
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secr... | |||
T3404 | Cucurbitacin B | Cuc B,DATISCACIN,Amarine | Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy |
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh... | |||
T1507 | Streptozocin | STZ,Streptozotocin,NSC-85998,U 9889 | DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy |
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th... | |||
T2978 | Mogroside V | AMPK | |
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce... | |||
T3867 | Alpinetin | (-)-alpinetin | BCL , PPAR |
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he... | |||
TWS2045 | Bruceine D | Apoptosis , Antiviral , Gamma-secretase , Parasite | |
1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW... | |||
T3849 | Kinsenoside | (+)-Kinsenoside | Apoptosis , Nrf2 |
Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou... | |||
T5S1389 | Escin IB | 5-HT Receptor , NO Synthase | |
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes... | |||
T3779 | Crocin II | Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B | Caspase , COX , NO Synthase |
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres... | |||
T3S0013 | Ethyl trans-caffeate | Ethyl caffeate,Caffeic Acid Ethyl Ester | Others |
1. Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) has anti-inflammatory activity. 2. Ethyl trans-caffeate may as a promising natural compound for future application in chronic liver disease. 3. Ethyl trans-caffeate is a... | |||
T4S0797 | Berberine | Berberin,Umbellatine | Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy |
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... | |||
T37512 | Cis-4-Hydroxy-L-proline | Endogenous Metabolite | |
cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress. | |||
T40464 | Neotheaflavin | ||
Neotheaflavin, from black tea, inhibits pancreatic lipase. | |||
TN5789 | Royleanone | ||
Royleanone possesses cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2. | |||
T20805 | Longikaurin E | (-)-Longikaurin E | Others |
Longikaurin E ((-)-Longikaurin E) is a therapeutic agent for pancreatic cancer. It is isolated from Isodon adenolomus. | |||
T13624 | Conophylline | Others | |
Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis. | |||
T20604 | Litorin | ||
Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion. | |||
TN4383 | Kazinol U | IL Receptor , IκB/IKK , NOS , NF-κB | |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-... | |||
TMA0805 | Lupanine | ATPase , Potassium Channel , Calcium Channel | |
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-chann... | |||
TN3118 | 5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) | Others | |
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity. | |||
T7711 | Uridine triphosphate | UTP,Uridine 5'-triphosphate | Others , Endogenous Metabolite |
Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. | |||
T83206 | Acanthopanaxoside A | ||
Acanthopanaxoside A, a triterpenoid saponin, exhibits inhibitory activity against pancreatic lipase [1]. | |||
T40584 | Corymbiferin | ||
Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of hi... | |||
T82712 | Ciwujianoside C4 | ||
Ciwujianoside C4, a saponin derivative, has been demonstrated to increase pancreatic lipase activity in vitro [1]. | |||
T82713 | Ciwujianoside C1 | ||
Ciwujianoside C1, a saponin derived from the leaves of Acanthopanax senticosus, exhibits in vitro inhibition of pancreatic lipase activity [1]. | |||
T80702 | α-Thevetin B | ||
α-Thevetin B (Compound 24), a cardiac glycoside extracted from Thevetia peruviana, has applications in research concerning lung, gastric, and pancreatic cancers [1]. | |||
T75645 | Echitamine chloride | ||
Echitamine chloride, the predominant monoterpene indole alkaloid found in Alstonia scholaris, exhibits significant anti-tumor activity by inducing DNA fragmentation and apoptosis. Furthermore, it effectively inhibits pan... | |||
T81701 | Nardoguaianone K | 10-epi-Nardoguaianone J | |
Nardoguaianone K, a guaiane-type sesquiterpenoid isolated from the roots of Nardostachys chinensis, has potential applications in pancreatic cancer research [1] [2]. | |||
T83308 | 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl | ||
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8), extracted from Dendrobium infundibulum (D. infundibulum), exhibits no inhibitory effects on α-glucosidase and pancreatic lipase [1]. | |||
TN5463 | Leachianone G | ||
Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Le... | |||
T36954 | Nemorosone | ||
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce... | |||
T38441 | Manzamine A hydrochloride | ||
Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to ... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-02846 | CLPS Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural... | |||
TMPY-04699 | GAD65 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoanti... | |||
TMPY-00084 | CLPS Protein, Rat, Recombinant (His) | Rat | HEK293 |
Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural... | |||
TMPJ-00743 | PPY Protein, Human, Recombinant (His) | Human | Human Cells |
PPY belongs to the NPY family and is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknow... | |||
TMPY-01729 | Carboxypeptidase A Protein, Human, Recombinant (His) | Human | HEK293 |
Carboxypeptidase A1 (CPA1)is secreted as a pancreatic procarboxypeptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group, with the preference of residues with aroma... | |||
TMPY-03222 | PNLIP Protein, Human, Recombinant (His) | Human | HEK293 |
PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found ... | |||
TMPY-00252 | PNLIPRP1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
PNLIPRP1, also known as PLRP1, belongs to the AB hydrolase superfamily, Lipase family. PNLIPRP1 is structurally similar to PLRP2. However, these two proteins display different functional properties. PNLIPRP1 may function... | |||
TMPY-01362 | Carboxypeptidase A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Carboxypeptidase A1 (CPA1)is secreted as a pancreatic procarboxypeptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group, with the preference of residues with aroma... | |||
TMPY-00529 | Alpha amylase/AMY2A Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
Alpha-amylase is the major form of amylase found in humans and other mammals. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first s... | |||
TMPY-03921 | Alpha amylase/AMY2A Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
Alpha-amylase is the major form of amylase found in humans and other mammals. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first s... | |||
TMPY-03182 | PLRP2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Galactolipase, also known as PNLIPRP2, is a lipase with broad substrate specificity. It can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactoli... | |||
TMPY-03808 | PNLIPRP1 Protein, Human, Recombinant (His) | Human | HEK293 |
PNLIPRP1, also known as PLRP1, belongs to the AB hydrolase superfamily, Lipase family. PNLIPRP1 is structurally similar to PLRP2. However, these two proteins display different functional properties. PNLIPRP1 may function... | |||
TMPY-03107 | Alpha amylase/AMY2A Protein, Human, Recombinant (His) | Human | HEK293 |
Alpha-amylase is the major form of amylase found in humans and other mammals. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first s... | |||
TMPY-00503 | Beta Amylase/AMY2B Protein, Human, Recombinant (His) | Human | HEK293 |
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. Alpha-amylase is the major fo... | |||
TMPY-00340 | Beta Amylase/AMY2B Protein, Human, Recombinant (hFc) | Human | HEK293 |
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. Alpha-amylase is the major fo... | |||
TMPY-03180 | Ribonuclease A Protein, Human, Recombinant (His) | Human | HEK293 |
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its... | |||
TMPY-01590 | GAD65 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoanti... | |||
TMPY-03515 | GAD65 Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoanti... | |||
TMPJ-00733 | SPINK1 Protein, Human, Recombinant (His) | Human | Human Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A dise... | |||
TMPJ-01108 | SMAD4 Protein, Human, Recombinant (His) | Human | E. coli |
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric... | |||
TMPY-04333 | LRRC15 Protein, Human, Recombinant (hFc) | Human | HEK293 |
LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb... | |||
TMPY-03221 | Intrinsic Factor Protein, Human, Recombinant (His) | Human | HEK293 |
Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the ... | |||
TMPY-00408 | PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05131 | PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-01897 | PRSS3 Protein, Human, Recombinant (His) | Human | HEK293 |
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains on... | |||
TMPY-05850 | CEACAM6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ... | |||
TMPY-04966 | PCSK9 Protein, Human, Recombinant (D374Y, His) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-00971 | CEACAM6 Protein, Human, Recombinant (His) | Human | HEK293 |
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ... | |||
TMPY-00665 | Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) | Human | HEK293 |
Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 fam... | |||
TMPY-02938 | REG4 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be inv... | |||
TMPY-02731 | SPINK4 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine... | |||
TMPY-01730 | CD24 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-03016 | CD24 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-01030 | TFPI Protein, Human, Recombinant (His) | Human | HEK293 |
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit... | |||
TMPY-02919 | Cadherin 17/CDH17 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-05352 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r... | |||
TMPY-04113 | KRAS Protein,Human,Recombinant(G12D & Q61H, His) | Human | E. coli |
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec... | |||
TMPY-01888 | KRAS Protein,Human, Recombinant (Q61H, His) | Human | E. coli |
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec... | |||
TMPY-06056 | KRAS Protein, Human, Recombinant (G12D, His) | Human | E. coli |
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec... | |||
TMPY-04116 | KRAS Protein,Human,Recombinant(G12C & Q61H, His) | Human | E. coli |
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec... | |||
TMPK-01327 | EPhA10 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPK-00999 | EPhA10 Protein, Human, Recombinant (His) | Human | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPK-01084 | EPhA10 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPY-03092 | REG1A Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-03684 | REG1A Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-01335 | REG1A Protein, Human, Recombinant (His) | Human | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-03353 | CEL Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activ... | |||
TMPK-00820 | AREG Protein, Human, Recombinant (hFc) | Human | HEK293 |
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic ca... | |||
TMPH-02823 | Peptide YY/PYY Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. | |||
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Cat No. | Product Name | ||
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L2192 | Anti-Pancreatic Cancer Compound Library | 2267 compounds | |
A unique collection of 2267 pancreatic cancer related compounds can be used in HTS and HCS; |