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Mepazine hydrochloride

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Catalog No. T61153Cas No. 2975-36-2
Alias Pecazine hydrochloride

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.

Mepazine hydrochloride

Mepazine hydrochloride

🥰Excellent
Purity: 99.76%
Catalog No. T61153Alias Pecazine hydrochlorideCas No. 2975-36-2
Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$56In Stock
25 mg$89In Stock
50 mg$128In Stock
100 mg$187In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Purity:99.76%
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Product Introduction

Bioactivity
Description
Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.
Targets&IC50
GSTMALT1 325-760:0.42 μM, GSTMALT1 FL:0.83 μM
In vitro
Mepazine hydrochloride was most effective in inhibiting GSTMALT1 FL and GSTMALT1 325-760 with IC50 values of 0.83 and 0.42 μM. Mepazine hydrochloride had the strongest effects and MALT1 activity was reduced by at least 75% in all ABC-DLBCL cells at 10 μM. Mepazine hydrochloride and thioridazine treatment led to a significant decrease of IL-2 secretion in PBMCs. [1]
In vivo
Mepazine hydrochloride and thioridazine could also exert effects on lymphoma growth in vivo in a murine DLBCL xenogeneic tumor model. Starting 1 day after injection, the mice were treated by intraperitoneal (i.p.) administration of solvent or either Mepazine hydrochloride (16 mg/kg) or thioridazine (12 mg/kg). In control-treated mice, massive tumors grew from both DLBCL cell lines within 3 weeks of transplantation. Daily administration of Mepazine hydrochloride or thioridazine strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. Mepazine hydrochloride and thioridazine strongly reduced the progression of OCI-Ly10 tumors while having no effect on the growth of Su-DHL-6 tumors in this setting. [1]
AliasPecazine hydrochloride
Chemical Properties
Molecular Weight346.92
FormulaC19H23ClN2S
Cas No.2975-36-2
SmilesCl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (115.30 mM), Sonication is recommended.
H2O: 1 mg/mL (2.88 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.8825 mL14.4125 mL28.8251 mL144.1254 mL
DMSO
1mg5mg10mg50mg
5 mM0.5765 mL2.8825 mL5.7650 mL28.8251 mL
10 mM0.2883 mL1.4413 mL2.8825 mL14.4125 mL
20 mM0.1441 mL0.7206 mL1.4413 mL7.2063 mL
50 mM0.0577 mL0.2883 mL0.5765 mL2.8825 mL
100 mM0.0288 mL0.1441 mL0.2883 mL1.4413 mL

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