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Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $56 | In Stock | |
25 mg | $89 | In Stock | |
50 mg | $128 | In Stock | |
100 mg | $187 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer. |
Targets&IC50 | GSTMALT1 325-760:0.42 μM, GSTMALT1 FL:0.83 μM |
In vitro | Mepazine hydrochloride was most effective in inhibiting GSTMALT1 FL and GSTMALT1 325-760 with IC50 values of 0.83 and 0.42 μM. Mepazine hydrochloride had the strongest effects and MALT1 activity was reduced by at least 75% in all ABC-DLBCL cells at 10 μM. Mepazine hydrochloride and thioridazine treatment led to a significant decrease of IL-2 secretion in PBMCs. [1] |
In vivo | Mepazine hydrochloride and thioridazine could also exert effects on lymphoma growth in vivo in a murine DLBCL xenogeneic tumor model. Starting 1 day after injection, the mice were treated by intraperitoneal (i.p.) administration of solvent or either Mepazine hydrochloride (16 mg/kg) or thioridazine (12 mg/kg). In control-treated mice, massive tumors grew from both DLBCL cell lines within 3 weeks of transplantation. Daily administration of Mepazine hydrochloride or thioridazine strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. Mepazine hydrochloride and thioridazine strongly reduced the progression of OCI-Ly10 tumors while having no effect on the growth of Su-DHL-6 tumors in this setting. [1] |
Alias | Pecazine hydrochloride |
Molecular Weight | 346.92 |
Formula | C19H23ClN2S |
Cas No. | 2975-36-2 |
Smiles | Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4 |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (115.30 mM), Sonication is recommended. H2O: 1 mg/mL (2.88 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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