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JNJ-67856633

Catalog No. T36670 CAS 2230273-76-2

JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.

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JNJ-67856633, CAS 2230273-76-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 563.00
100 mg	In stock	$ 791.00
1 mL * 10 mM (in DMSO)	In stock	$ 117.00

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Biological Description

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Description	JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.
In vitro	JNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors[1][3].
In vivo	Dose dependent inhibition of the generation of Tregs (CD4+CD25+FoxP3+) following CD3/28 stimulation was observed upon treatment with JNJ-67856633 suggesting a potential immune modulatory role of MALT1 inhibition[3].

Molecular Weight	467.32
Formula	C20H11F6N5O2
CAS No.	2230273-76-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (267.48 mM), Sonification is recommended.

References and Literature

1. Virtual meeting delivers first time drug structures 2. A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-67856633, an Inhibitor of MALT1, in Participants with NHL and CLL 3. Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Compound Library Orally Active Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Mepazine MIR96-IN-1 MLT-943 MALT1 inhibitor MI-2

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Keywords

JNJ-67856633 2230273-76-2 Immunology/Inflammation MALT inhibit active allosteric orally selective mucosa associated lymphoid tissue lymphoma translocation gene 1 Inhibitor JNJ67856633 MALT1 potent JNJ 67856633 inhibitor

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