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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
2 mg | $68 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $189 | In Stock | |
25 mg | $363 | In Stock | |
50 mg | $563 | In Stock | |
100 mg | $791 | In Stock | |
1 mL x 10 mM (in DMSO) | $117 | In Stock |
Description | JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases. |
In vitro | JNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors[1][3]. |
In vivo | Treatment with JNJ-67856633 was observed to cause dose-dependent inhibition of Tregs (CD4+CD25+FoxP3+) generation following CD3/28 stimulation, suggesting a potential immune-modulatory role of MALT1 inhibition[3]. |
Molecular Weight | 467.32 |
Formula | C20H11F6N5O2 |
Cas No. | 2230273-76-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (267.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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