NVS-MALT1 is an allosteric inhibitor of MALT1 [1].

MALT1-IN-11, a potent MALT1 protease inhibitor (IC 50 < 10 nM), effectively reduces IL10 secretion, exhibiting an IC 50 between 10-100 nM. This compound is primarily utilized in the study of cancer, autoimmune, and inflammatory disorders.

MALT1-IN-8 is a potent inhibitor of MALT1 protease (IC50: 2 nM). MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells (IC50: 1.16 μM) and exhibits anticancer activity.

MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.

MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.

(R)-MALT1-IN-3 (compound 121) is a potent inhibitor of MALT1 protease (IC50: 20 nM) with IC50 values of 60 nM and 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.

(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.

MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.

(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits MALT1 activity and has the potential to improve the enhancement of MALT1 activity caused by abnormal T-cell receptor signalling or B-cell receptor signalling, as well as cancer or inflammatory diseases caused by MALT1 activity. (S)-MALT1-IN-5 has potential for MALT1-related disease studies.

MALT1-IN-9 (WO2021000855A1, Compound 5), a highly potent inhibitor of MALT1 protease, demonstrates an IC50 value of <500 nM when tested in Raji MALT1-GloSensor cells. MALT1-IN-9 exhibits significant anticancer properties [1].

MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.

Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.

Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible inhibitor of lymphoma translocation protein 1 (MALT1) in mucosa-associated lymphoid tissue.

Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

Mepazine hydrochloride monohydrate is a MALT1 inhibitor.

MLT-231, a potent and highly selective allosteric MALT1 inhibitor, has an IC50 of 9 nM and specifically inhibits endogenous BCL10 cleavage with an IC50 of 160 nM. It exhibits antitumor activity in an ABC-DLBCL type xenograft mouse model[1].

Z-VRPR-FMK, an irreversible inhibitor of the MALT1 protein, effectively suppresses the proliferation and invasion of diffuse large B-cell lymphoma. This is achieved through the inhibition of MALT1-induced NF-κB activation and MMP (matrix metalloproteinase) expression.

MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.

MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].

(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.

MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).

Val-Arg-Pro-DL-Arg-Fluoromethylketone, a potent MALT1 inhibitor, exhibits anticancer activity by inhibiting cell proliferation and migration [1].

JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.

MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.

Z-VRPR-FMK (TFA), a selective and irreversible inhibitor of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), is a tetrapeptide shown to provide protection against influenza A virus (IAV) infection [1].

Mepazine acetate is a MALT1 inhibitor.

RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and influences the viability of ABC-DLBCL cells [1].