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Mepazine

🥰Excellent
Catalog No. T16040Cas No. 60-89-9
Alias Pecazine

Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.

Mepazine

Mepazine

🥰Excellent
Purity: 99.99%
Catalog No. T16040Alias PecazineCas No. 60-89-9
Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.
Pack SizePriceAvailabilityQuantity
10 mg$33 In Stock
25 mg$55 In Stock
50 mg$85 In Stock
100 mg$118 In Stock
200 mg$187 In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$30 In Stock
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Purity:99.99%
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Product Introduction

Bioactivity
Description
Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.
In vitro
Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells[1].
In vivo
In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration[1].
AliasPecazine
Chemical Properties
Molecular Weight310.46
FormulaC19H22N2S
Cas No.60-89-9
SmilesCN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Relative Density.1.1252 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (80.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2210 mL16.1051 mL32.2103 mL161.0513 mL
5 mM0.6442 mL3.2210 mL6.4421 mL32.2103 mL
10 mM0.3221 mL1.6105 mL3.2210 mL16.1051 mL
20 mM0.1611 mL0.8053 mL1.6105 mL8.0526 mL
50 mM0.0644 mL0.3221 mL0.6442 mL3.2210 mL

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