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Clobenpropit dihydrobromide

Clobenpropit dihydrobromide
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Purity:99.48%
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Clobenpropit dihydrobromide

Catalog No. T8439Cas No. 145231-35-2
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)
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Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$89In Stock
10 mg$155In Stock
25 mg$347In Stock
50 mg$587In Stock
100 mg$839In Stock
1 mL x 10 mM (in DMSO)$108In Stock
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Product Introduction

Bioactivity
Description
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)
Targets&IC50
H4 receptor:13 nM (Ki), H3LR (human):9.44 (pKi), H2 receptor:5.6 (pKi), H3LR (rat):9.75 (pKi)
In vitro
Clobenpropit inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine.?Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction[1].
In vivo
Clobenpropit inhibited tumor growth (gemcitabine 294 46 mg vs combination 154 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.
Cell Research
Pancreatic cancer cells (Panc-1, MiaPaCa-2 and AsPC-1).Concentration: 50 Μm
Chemical Properties
Molecular Weight470.7
FormulaC14H19Br2ClN4S
Cas No.145231-35-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.71 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1245 mL10.6225 mL21.2450 mL106.2248 mL
5 mM0.4249 mL2.1245 mL4.2490 mL21.2450 mL
10 mM0.2124 mL1.0622 mL2.1245 mL10.6225 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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