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CMC2.24
Catalog No. T36492Cas No. 1255639-43-0
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].
CMC2.24
Catalog No. T36492Cas No. 1255639-43-0
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $985 | 6-8 weeks | |
| 50 mg | $1,280 | 6-8 weeks | |
| 100 mg | $1,940 | 6-8 weeks |
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Chemical Properties
| Description | CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3]. |
| Targets&IC50 | MMP7:5 μM (IC50), MMP2:4.8 μM (IC50), MMP13:2.7 μM (IC50), MMP9:8 μM (IC50), MMP1:69.8 μM (IC50), MMP12:2 μM (IC50), MMP8:4.5 μM (IC50), MMP14:15.3 μM (IC50), MMP3:2.9 μM (IC50) |
| In vitro | CMC2.24 (0-60 μM; 24 hours) inhibits pancreatic cancer growth in vitro by reducing STAT3Ser727 phosphorylation levels, inducing mitochondrial reactive oxygen species, and promoting intrinsic apoptosis and mitochondrial cell death in pancreatic cancer cells[1]. |
| In vivo | CMC2.24 (50 mg/kg; p.o.; five times per week for 17 days) inhibits pancreatic cancer xenograft growth and human PC through a potent cytokinetic effect, and disrupts the ERK signaling pathway in PC cells and xenografts[1]. |
| Molecular Weight | 427.45 |
| Formula | C26H21NO5 |
| Cas No. | 1255639-43-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble) |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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