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FGTI-2734 mesylate (1247018-19-4 free base)

Name: FGTI-2734 mesylate (1247018-19-4 free base)
Brand: TargetMol
SKU: T11282L
Rating: 4.5 (1 reviews)

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Catalog No. T11282LCas No. 2702297-24-1

Alias FGTI-2734 mesylate

FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.

FGTI-2734 mesylate (1247018-19-4 free base)

😃Good

Catalog No. T11282LAlias FGTI-2734 mesylateCas No. 2702297-24-1

Pack Size	Price	Availability
25 mg	$2,130	8-10 weeks
50 mg	$3,210	8-10 weeks
100 mg	$3,730	8-10 weeks

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Product Introduction

Bioactivity

Description	FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
Targets&IC50	GGT:520 nM , FT:250 nM
In vitro	FGTI-2734 mesylate (3-30 μM;?72 hours) inhibits both protein prenylation of HDJ2, RAP1A, KRAS and NRAS. FGTI-2734 mesylate (1-30 μM; 72 hours) induces apoptosis in mutant KRAS-dependent, but not mutant KRAS- independent, human cancer cells. ??FGTI-2734 inhibits KRAS membrane localization in RAS-transformed murine NIH3T3 cells and in mutant KRAS human cancer cells.
In vivo	FGTI-2734 mesylate (intraperitoneally;?100 mg/kg/day for 18 to 25 days) only inhibits tumor growth in mutant KRAS-dependent tumors but not in mutant KRAS-independent tumors.
Alias	FGTI-2734 mesylate

Chemical Properties

Molecular Weight	606.73
Formula	C₂₇H₃₅FN₆O₅S₂
Cas No.	2702297-24-1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 75 mg/mL (123.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6482 mL	8.2409 mL	16.4818 mL	82.4090 mL
5 mM	0.3296 mL	1.6482 mL	3.2964 mL	16.4818 mL
10 mM	0.1648 mL	0.8241 mL	1.6482 mL	8.2409 mL
20 mM	0.0824 mL	0.4120 mL	0.8241 mL	4.1204 mL
50 mM	0.0330 mL	0.1648 mL	0.3296 mL	1.6482 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.8241 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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