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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,690 | Backorder |
Description | Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis. |
In vitro | Conophylline (100 ng/ml; 48 hours) reproduces differentiation-inducing activity but not the apoptosis-inducing activity of activin. Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells. Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells [1]. Conophylline inhibits DNA synthesis induced by serum. Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells. Conophylline also promotes activation of caspase-3 and induces apoptosis in Lx-2 Cells [2]. |
In vivo | Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates the formation of the liver fibrosis induced by TAA in vivo [2]. |
Molecular Weight | 794.89 |
Formula | C44H50N4O10 |
Cas No. | 142741-24-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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