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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $51 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $396 | In Stock | |
50 mg | $663 | In Stock | |
100 mg | $1,060 | In Stock | |
500 mg | $2,120 | In Stock | |
1 mL x 10 mM (in DMSO) | $133 | In Stock |
Description | PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cancer. |
In vitro | PKI-166 (0–0.5 μM; 1 hour) pretreatment suppresses EGFR autophosphorylation in human pancreatic cancer cells. PKI-166 (0.03μ M; 6 days) increased the cytotoxicity mediated by gemcitabine.[1] |
In vivo | PKI-166 (100 mg/kg; p.o.; daily; day 7-day 35 after xenograft) suppresses the growth of pancreatic cancer.[1] |
Molecular Weight | 330.38 |
Formula | C20H18N4O |
Cas No. | 187724-61-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (83.23 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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