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Product Introduction

Bioactivity

Description	Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma.
In vitro	Colchicoside (1 and 10 μM) increases levels of CYP2C9 and CYP2E1 in primary human hepatocytes[3].
Alias	3-Demethylcolchicine glucoside

Chemical Properties

Molecular Weight	547.55
Formula	C₂₇H₃₃NO₁₁
Cas No.	477-29-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMF: 27.0 mg/mL (49.3 mM)

DMSO: 27.0 mg/mL (49.3 mM)

PBS (pH 7.2): 10 mg/mL

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8263 mL	9.1316 mL	18.2632 mL	91.3159 mL
5 mM	0.3653 mL	1.8263 mL	3.6526 mL	18.2632 mL
10 mM	0.1826 mL	0.9132 mL	1.8263 mL	9.1316 mL
20 mM	0.0913 mL	0.4566 mL	0.9132 mL	4.5658 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Colchicoside