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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $30 | In Stock | |
50 mg | $42 | In Stock | |
100 mg | $58 | In Stock | |
200 mg | $96 | In Stock | |
250 mg | $124 | In Stock | |
500 mg | $181 | In Stock | |
1 mL x 10 mM (in DMSO) | $46 | In Stock |
Description | Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
In vitro | In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1] |
In vivo | Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3]. |
Alias | 2-Pyridinecarboxamide, 2-Carbamoylpyridine, 2-Picolinamide, Picolinoylamide |
Molecular Weight | 122.12 |
Formula | C6H6N2O |
Cas No. | 1452-77-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 23 mg/mL (188.3 mM) DMSO: 45 mg/mL (368.49 mM) H2O: 22 mg/mL (180.2 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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