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EB-47

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Purity:99.86%

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COA HPLC HNMR

EB-47

Catalog No. T11143Cas No. 366454-36-6

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

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Pack Size	Price	Availability
1 mg	$62	In Stock
5 mg	$133	In Stock
10 mg	$223	In Stock
25 mg	$397	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Product Introduction

Bioactivity

Description	EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.
Targets&IC50	ARTD1/PARP1:45 nM
In vitro	The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%[1].
In vivo	EB-47, at a concentration of 2 μM for a duration of 5 days, reduces the number of embryo implantation sites and the quantity of blastocysts observed on day 5. PARP1 is involved in the embryo implantation process[1].

Chemical Properties

Molecular Weight	537.53
Formula	C24H27N9O6
Cas No.	366454-36-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (111.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8604 mL	9.3018 mL	18.6036 mL	93.0181 mL
5 mM	0.3721 mL	1.8604 mL	3.7207 mL	18.6036 mL
10 mM	0.1860 mL	0.9302 mL	1.8604 mL	9.3018 mL
20 mM	0.0930 mL	0.4651 mL	0.9302 mL	4.6509 mL
50 mM	0.0372 mL	0.1860 mL	0.3721 mL	1.8604 mL
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9302 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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