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Tigatuzumab
🥰Excellent
Catalog No. T76793Cas No. 918127-53-4
Alias TRA-8, TRA8, CS-1008, CS1008, Anti-Human TRAIL-R2 Recombinant Antibody
Tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5 (DR5), is a TRAIL-R2 agonist with antitumor activity that induces apoptosis in cancer cells, and can be used to study pancreatic cancer.
Tigatuzumab
Tigatuzumab
🥰Excellent
Purity: 95%
Catalog No. T76793Alias TRA-8, TRA8, CS-1008, CS1008, Anti-Human TRAIL-R2 Recombinant AntibodyCas No. 918127-53-4
Tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5 (DR5), is a TRAIL-R2 agonist with antitumor activity that induces apoptosis in cancer cells, and can be used to study pancreatic cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $589 | In Stock | |
| 10 mg | $993 | In Stock | |
| 25 mg | $1,470 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Concentration:9.15 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5 (DR5), is a TRAIL-R2 agonist with antitumor activity that induces apoptosis in cancer cells, and can be used to study pancreatic cancer. |
| Targets&IC50 | MIAPaCa2 cells:2.95 μg/mL |
| In vitro | Tigatuzumab showed sensitivity to MIA PaCa-2 cells and BxPC-3 cells with IC50 values of 2.95 μg/mL and 8.21 μg/mL, respectively.[1] Tigatuzumab (3-8 μg/mL; 5 hours) was able to induce apoptosis in cancer cells. [1] |
| In vivo | Tigatuzumab (3 mg/kg; i.v.; once weekly for 4 weeks) was effective in inhibiting tumor growth of human pancreatic cancer MIA PaCa-2-RFP in a xenograft mouse model. [1] |
| Alias | TRA-8, TRA8, CS-1008, CS1008, Anti-Human TRAIL-R2 Recombinant Antibody |
| Molecular Weight | 144.6 (kDa) |
| Cas No. | 918127-53-4 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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