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Dorzagliatin

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Purity:99.74%

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COA HPLC HNMR

Dorzagliatin

Catalog No. T15159Cas No. 1191995-00-2

Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$79	In Stock
10 mg	$125	In Stock
25 mg	$253	In Stock
50 mg	$397	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Product Introduction

Bioactivity

Description	Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
In vivo	In diabetic rats, Dorzagliatin (low-dose 10?mg/kg, and high-dose 30?mg/kg; administered intragastrically; daily 8:00 AM for one month) shows a glucose-lowering effect on the glucose levels[2].
Alias	HMS5552

Chemical Properties

Molecular Weight	462.93
Formula	C22H27ClN4O5
Cas No.	1191995-00-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (270.02 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1602 mL	10.8008 mL	21.6015 mL	108.0077 mL
5 mM	0.4320 mL	2.1602 mL	4.3203 mL	21.6015 mL
10 mM	0.2160 mL	1.0801 mL	2.1602 mL	10.8008 mL
20 mM	0.1080 mL	0.5400 mL	1.0801 mL	5.4004 mL
50 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1602 mL
100 mM	0.0216 mL	0.1080 mL	0.2160 mL	1.0801 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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