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ML251

Catalog No. T64320Cas No. 1486482-16-9

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

ML251

ML251

Purity: 99.87%
Catalog No. T64320Cas No. 1486482-16-9
ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Pack SizePriceAvailabilityQuantity
1 mg$135In Stock
5 mg$289In Stock
10 mg$455In Stock
25 mg$753In Stock
50 mg$1,060In Stock
100 mg$1,430In Stock
500 mg$2,860In Stock
1 mL x 10 mM (in DMSO)$317In Stock
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Purity:99.87%
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Product Introduction

Bioactivity
Description
ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Targets&IC50
PFK (T. cruzi):0.13 μM, PFK (T. b. brucei):0.37 μM
In vitro
ML251 produces modest dose-dependent toxicity[1].
Cell Research
The cell cytotoxicity assay of ML251 (0~33.3 μg/mL) in T. brucei cell shows dose-dependent reduction of cell viability[1].
Chemical Properties
Molecular Weight426.27
FormulaC17H13Cl2N3O4S
Cas No.1486482-16-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (117.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3459 mL11.7297 mL23.4593 mL117.2965 mL
5 mM0.4692 mL2.3459 mL4.6919 mL23.4593 mL
10 mM0.2346 mL1.1730 mL2.3459 mL11.7297 mL
20 mM0.1173 mL0.5865 mL1.1730 mL5.8648 mL
50 mM0.0469 mL0.2346 mL0.4692 mL2.3459 mL
100 mM0.0235 mL0.1173 mL0.2346 mL1.1730 mL

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