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Almorexant hydrochloride
🥰Excellent
Catalog No. T6155Cas No. 913358-93-7
Alias Orexin-RA-1 hydrochloride, ACT-078573 hydrochloride, ACT 078573 hydrochloride, A 573 hydrochloride
Almorexant hydrochloride (ACT 078573 hydrochloride) is an orally active dual orexin receptor antagonist that blocks the intracellular Ca2+ signaling pathway and, to a certain extent, blocks the excitatory effects of methamphetamine. Almorexant hydrochloride Induces apoptosis and can be used to study sleep disorders.
Almorexant hydrochloride
🥰Excellent
Catalog No. T6155Alias Orexin-RA-1 hydrochloride, ACT-078573 hydrochloride, ACT 078573 hydrochloride, A 573 hydrochlorideCas No. 913358-93-7
Almorexant hydrochloride (ACT 078573 hydrochloride) is an orally active dual orexin receptor antagonist that blocks the intracellular Ca2+ signaling pathway and, to a certain extent, blocks the excitatory effects of methamphetamine. Almorexant hydrochloride Induces apoptosis and can be used to study sleep disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $90 | In Stock | |
| 10 mg | $146 | In Stock | |
| 25 mg | $343 | In Stock | |
| 50 mg | $549 | In Stock | |
| 100 mg | $828 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Almorexant hydrochloride (ACT 078573 hydrochloride) is an orally active dual orexin receptor antagonist that blocks the intracellular Ca2+ signaling pathway and, to a certain extent, blocks the excitatory effects of methamphetamine. Almorexant hydrochloride Induces apoptosis and can be used to study sleep disorders. |
| Targets&IC50 | OX1:1.3 nM(ki), OX2:0.17 nM(ki) |
| In vitro | AsPC-1 cells preincubated or not with the SHP2 inhibitor NSC-87877 (50 μM) were challenged for 5 min without or with 1 μM orexin-A or 1 μM Almorexant hydrochloride. In parallel, HPAF-II cells were also challenged for 5 min without or with 1 μM orexin-A. Orexin-A and Almorexant hydrochloride promote tyrosine phosphorylation of SHP2/OX1R complex. [1] |
| In vivo | Daily intraperitoneal injection of Almorexant hydrochloride (1.8 μmol/kg) at day 0 in mice xenografted with AsPC-1 cells and up to the mice sacrifices resulted in a significant decrease in tumor volume (> 50%), as compared to untreated mice. Treatment with Almorexant hydrochloride started after AsPC-1 tumors were developed, rapidly and strongly reduced the volume of established tumors. OX1R expression revealed by immunodetection was not affected by Almorexant hydrochloride treatment. [1] |
| Alias | Orexin-RA-1 hydrochloride, ACT-078573 hydrochloride, ACT 078573 hydrochloride, A 573 hydrochloride |
| Molecular Weight | 549.02 |
| Formula | C29H32ClF3N2O3 |
| Cas No. | 913358-93-7 |
| Smiles | C(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2C=3C(=CC(OC)=C(OC)C3)CCN2[C@@H](C(NC)=O)C4=CC=CC=C4.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 48 mg/mL (87.4 mM) DMSO: 40 mg/mL (72.86 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
narcolepsyInhibitorCaspaseHPAF-II cellsACT078573ACT078573 HydrochloridePDACAlmorexant HClGPCRCa2+ channelsPancreatic ductal adenocarcinomaApoptosisOrexin Receptor (OX Receptor)Ca channelsAsPC-1 cellshypocretinCataplexyHCRT ReceptorHypocretin ReceptorCalcium ChannelACT 078573orexinpancreatic cancerACT-078573inhibitAlmorexant
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