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TNG-462

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Catalog No. T79873Cas No. 2760483-96-1
Alias TNG462

TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).

TNG-462

TNG-462

🥰Excellent
Catalog No. T79873Alias TNG462Cas No. 2760483-96-1
TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).
Pack SizePriceAvailabilityQuantity
1 mg$510 In Stock
5 mg$1,120 In Stock
10 mg$1,760 In Stock
25 mg$2,990 In Stock
50 mg$4,620 In Stock
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Product Introduction

Bioactivity
Description
TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).
In vitro
Methods: Tumor cells (NSCLC, PDAC, bladder, hematological malignancies) deficient in MTAP were treated with TNG-462 (0-1 μM) and cell viability was measured.
Results: TNG-462 selectively inhibited cell viability with an IC50 value of less than 1 μM. [2]
In vivo
Methods: TNG-462 (40 mg twice a day; 100 mg/kg twice a day, orally, for 21 days) was used to treat a xenograft mouse model derived from a MTAP-deficient cell line and observe tumor growth in vivo.
Results: TNG-462 inhibited tumor growth in mice and showed anti-tumor activity. [2]
AliasTNG462
Chemical Properties
Molecular Weight520.69
FormulaC28H36N6O2S
Cas No.2760483-96-1
SmilesC(C(NC=1C=C(CC)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC(=N4)C5CCN(C)CC5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (153.64 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9205 mL9.6026 mL19.2053 mL96.0264 mL
5 mM0.3841 mL1.9205 mL3.8411 mL19.2053 mL
10 mM0.1921 mL0.9603 mL1.9205 mL9.6026 mL
20 mM0.0960 mL0.4801 mL0.9603 mL4.8013 mL
50 mM0.0384 mL0.1921 mL0.3841 mL1.9205 mL
100 mM0.0192 mL0.0960 mL0.1921 mL0.9603 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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