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TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $510 | In Stock | |
5 mg | $1,120 | In Stock | |
10 mg | $1,760 | In Stock | |
25 mg | $2,990 | In Stock | |
50 mg | $4,620 | In Stock |
Description | TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies). |
In vitro | Methods: Tumor cells (NSCLC, PDAC, bladder, hematological malignancies) deficient in MTAP were treated with TNG-462 (0-1 μM) and cell viability was measured. Results: TNG-462 selectively inhibited cell viability with an IC50 value of less than 1 μM. [2] |
In vivo | Methods: TNG-462 (40 mg twice a day; 100 mg/kg twice a day, orally, for 21 days) was used to treat a xenograft mouse model derived from a MTAP-deficient cell line and observe tumor growth in vivo. Results: TNG-462 inhibited tumor growth in mice and showed anti-tumor activity. [2] |
Alias | TNG462 |
Molecular Weight | 520.69 |
Formula | C28H36N6O2S |
Cas No. | 2760483-96-1 |
Smiles | C(C(NC=1C=C(CC)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC(=N4)C5CCN(C)CC5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (153.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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