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KRAS inhibitor-12

Catalog No. T62751Cas No. 2230874-00-5

KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.

KRAS inhibitor-12

KRAS inhibitor-12

Catalog No. T62751Cas No. 2230874-00-5
KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.
Pack SizePriceAvailabilityQuantity
25 mg$2,1408-10 weeks
50 mg$2,7858-10 weeks
100 mg$3,5208-10 weeks
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Product Introduction

Bioactivity
Description
KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.
Chemical Properties
Molecular Weight452.33
FormulaC19H16Cl2FN5OS
Cas No.2230874-00-5
Storage & Solubility Information
StorageShipping with blue ice.

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