CDH17 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00583

Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks the conserved cytoplasmic domain. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherins are calcium dependent cell adhesion proteins and preferentially interact with each other in a homophilic manner in connecting cells. Cadherin-17 may have a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.

CDH17 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00583

Pack Size	Price	Availability
10 μg	$184	7-10 days
50 μg	$545	7-10 days
500 μg	$1,900	7-10 days
1 mg	$2,730	7-10 days

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Product Information

Biological Activity	1. Immobilized CDH17 Protein, Human, Recombinant (His) at 2 μg/mL (100 μL/well) can bind Anti-Human Cadherin-17 mab (Human IgG1). The ED50 of Anti-Human Cadherin-17 mab (Human IgG1) is 7.34 ng/mL. (Regularly tested). _x000D_ 2. Loaded Anti-Human Cadherin-17 mab (Human IgG1) on Pro-A Biosensor, can bind CDH17 Protein, Human, Recombinant (His) with an affinity constant of 0.827 uM as determined in BLI assay. (Regularly tested)
Description	Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks the conserved cytoplasmic domain. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherins are calcium dependent cell adhesion proteins and preferentially interact with each other in a homophilic manner in connecting cells. Cadherin-17 may have a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	AAI13465.1
Synonyms	Liver-Intestine Cadherin,LI-Cadherin,Intestinal Peptide-Associated Transporter HPT-1,CDH17,Cadherin-17
Amino Acid	Gln23-Met787
Construction	Gln23-Met787
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Molecular Weight	110-130 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks the conserved cytoplasmic domain. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherins are calcium dependent cell adhesion proteins and preferentially interact with each other in a homophilic manner in connecting cells. Cadherin-17 may have a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.