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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $46 | In Stock | |
2 mg | $66 | In Stock | |
5 mg | $109 | In Stock | |
10 mg | $176 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $526 | In Stock | |
100 mg | $763 | In Stock | |
200 mg | $1,070 | In Stock | |
500 mg | $1,590 | In Stock | |
1 mL x 10 mM (in DMSO) | $90 | In Stock |
Description | E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
In vitro | E3330 affects hemangioblast development in vitro via inhibition of Ape1 redox activity. [1] E3330 inhibits the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibits the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. [2] In JHH6 cells, E3330 prevents the functional activation of NF-κB via the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage of the redox-mediated activation of NF-κB. [3] |
In vivo | In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuates the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. [4] In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine. [5] |
Cell Research | PANC1 cells are placed in one well of a 12-well plate and treated with 5 to 30 μM E3330. After a 24, 48, and 72 h of culture, the cells are washed with PBS and stained with trypan blue, and cell viability is examined by counting the live cell numbers.(Only for Reference) |
Molecular Weight | 378.46 |
Formula | C21H30O6 |
Cas No. | 136164-66-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (132.11 mM), Sonication is recommended. ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 70 mg/mL (185 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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