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N-Nitrosodiethylamine

N-Nitrosodiethylamine
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Purity:99.26%
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N-Nitrosodiethylamine

Catalog No. T35455Cas No. 55-18-5
N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the liver, nasal cavity, trachea, lung and esophagus.
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Pack SizePriceAvailabilityQuantity
500 mg$41In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Related Compound Libraries of "N-Nitrosodiethylamine"

Product Introduction

Bioactivity
Description
N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in water, tobacco smoke, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the liver, nasal cavity, trachea, lung and esophagus.
In vivo
Mice with N-Nitrosodiethylamine (25mg/kg) intraperitonially resulted in fatty liver disease leading to progress of cancer disease.
AliasDiethylnitrosamine, NDEA
Chemical Properties
Molecular Weight102.14
FormulaC4H10N2O
Cas No.55-18-5
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 98 mg/mL (959.47 mM)
DMSO: 50 mg/mL (489.52 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM9.7905 mL48.9524 mL97.9048 mL489.5242 mL
5 mM1.9581 mL9.7905 mL19.5810 mL97.9048 mL
10 mM0.9790 mL4.8952 mL9.7905 mL48.9524 mL
20 mM0.4895 mL2.4476 mL4.8952 mL24.4762 mL
50 mM0.1958 mL0.9790 mL1.9581 mL9.7905 mL
100 mM0.0979 mL0.4895 mL0.9790 mL4.8952 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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