Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

BRD7389

🥰Excellent
Catalog No. T14779Cas No. 376382-11-5

BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.

BRD7389

BRD7389

🥰Excellent
Purity: 99.17%
Catalog No. T14779Cas No. 376382-11-5
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Pack SizePriceAvailabilityQuantity
2 mg27 €In Stock
5 mg43 €In Stock
10 mg60 €In Stock
25 mg93 €In Stock
50 mg140 €In Stock
100 mg207 €In Stock
1 mL x 10 mM (in DMSO)52 €In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "BRD7389"

Select Batch
Purity:99.17%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Targets&IC50
RSK1:1.5 μM, RSK2:2.4 μM, PKG1α:6.5 μM, SGK:13.8 μM, RSK3:1.2 μM, FLT3:3.5 μM, CDK5-p35:6.5 μM, Pim1:3.7 μM, DRAK1:2.8 μM
In vitro
BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2].
Chemical Properties
Molecular Weight366.41
FormulaC24H18N2O2
Cas No.376382-11-5
SmilesO=C1c2ccccc2-c2c(NCCc3ccccc3)c(=O)[nH]c3cccc1c23
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (54.58 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7292 mL13.6459 mL27.2918 mL136.4592 mL
5 mM0.5458 mL2.7292 mL5.4584 mL27.2918 mL
10 mM0.2729 mL1.3646 mL2.7292 mL13.6459 mL
20 mM0.1365 mL0.6823 mL1.3646 mL6.8230 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7292 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy BRD7389 | purchase BRD7389 | BRD7389 cost | order BRD7389 | BRD7389 chemical structure | BRD7389 in vitro | BRD7389 formula | BRD7389 molecular weight