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DSPE-PEG(2000) Maleimide

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Catalog No. T201897Cas No. 185844-12-6
Alias 1,2-DSPE-PEG(2000)-Mal, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-PEG-2000 Maleimide, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000], 1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine-N-[maleimide(polyethylene glycol)-2000]

DSPE-PEG(2000) maleimide is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE). This compound is frequently utilized both in vitro and in vivo for synthesizing lipid nanoparticles (LNPs) that deliver siRNA or small molecule anticancer drugs. In experiments, LNPs containing DSPE-PEG(2000) maleimide and encapsulating siRNA targeting the mRNAs for p53 and K-RAS induced tumor regression in a PANC-1 pancreatic ductal adenocarcinoma mouse xenograft model.

DSPE-PEG(2000) Maleimide

DSPE-PEG(2000) Maleimide

😃Good
Catalog No. T201897Alias 1,2-DSPE-PEG(2000)-Mal, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-PEG-2000 Maleimide, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000], 1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine-N-[maleimide(polyethylene glycol)-2000]Cas No. 185844-12-6
DSPE-PEG(2000) maleimide is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE). This compound is frequently utilized both in vitro and in vivo for synthesizing lipid nanoparticles (LNPs) that deliver siRNA or small molecule anticancer drugs. In experiments, LNPs containing DSPE-PEG(2000) maleimide and encapsulating siRNA targeting the mRNAs for p53 and K-RAS induced tumor regression in a PANC-1 pancreatic ductal adenocarcinoma mouse xenograft model.
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Product Introduction

Bioactivity
Description
DSPE-PEG(2000) maleimide is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE). This compound is frequently utilized both in vitro and in vivo for synthesizing lipid nanoparticles (LNPs) that deliver siRNA or small molecule anticancer drugs. In experiments, LNPs containing DSPE-PEG(2000) maleimide and encapsulating siRNA targeting the mRNAs for p53 and K-RAS induced tumor regression in a PANC-1 pancreatic ductal adenocarcinoma mouse xenograft model.
Alias1,2-DSPE-PEG(2000)-Mal, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-PEG-2000 Maleimide, 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000], 1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine-N-[maleimide(polyethylene glycol)-2000]
Chemical Properties
Formula(C2H4O)nC51H92N3O13P
Cas No.185844-12-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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