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Secretin (swine)

Name: Secretin (swine)
Brand: TargetMol
SKU: T81182
Rating: 4.5 (1 reviews)

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Catalog No. T81182Cas No. 17034-35-4

Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2].

Secretin (swine)

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Catalog No. T81182Cas No. 17034-35-4

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Product Introduction

Bioactivity

Description	Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2].
In vitro	Secretin (swine) at concentrations of 10−7 M and 10−6 M, administered over periods ranging from 24 hours to 72 hours and up to 7 days, enhances biliary growth through engagement with secretin receptors (SR). Additionally, SR knockout diminishes biliary proliferation by attenuating cAMP-dependent signaling pathways [2].
In vivo	Secretin (swine) administered at 2.5 nM/kg body weight per day via osmotic minipumps for one week induces biliary cell proliferation in mice by modulating the levels of microRNA 125b and microRNA let7a [2].

Chemical Properties

Molecular Weight	3055.41
Formula	C₁₃₀H₂₂₀N₄₄O₄₁
Cas No.	17034-35-4

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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