Shopping Cart
- Remove All
- Your shopping cart is currently empty
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $158 | In Stock | |
25 mg | $286 | In Stock | |
50 mg | $429 | In Stock | |
100 mg | $596 | In Stock | |
200 mg | $788 | In Stock | |
1 mL x 10 mM (in DMSO) | $115 | In Stock |
Description | TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay. |
Targets&IC50 | Raf:62 nM (BRAF V600E kinase assay), Raf:18 nM (Cell-Based Phosho-ERK Assay) |
In vitro | The IC50 values of TBAP-001 are 178 nM (A375), 62 nM (WM266.4), 72 nM (UACC62), 93 nM (LOX INVI), 590 nM (HT 29), 43 nM (COLO225), 690 nM (RKO), 490 nM (Mawi), 390 nM (WiDr), 480 nM (Colo741), 480 nM (SW620), 600 nM (HCT116), 390 nM (SKMEL2), 710 nM (D04), 390 nM (WM1361), 1150 nM (PDAC R172H (p53 mut)), 290 nM (MiaPaCa) and 490nM (RPMI8226) in different cancer cell lines[1]. |
Molecular Weight | 531.51 |
Formula | C27H23F2N7O3 |
Cas No. | 1777832-90-2 |
Smiles | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(F)c1 |
Relative Density. | 1.42 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (470.36 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.