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TBAP-001

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Catalog No. T9693Cas No. 1777832-90-2

TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.

TBAP-001

TBAP-001

🥰Excellent
Purity: 99.3%
Catalog No. T9693Cas No. 1777832-90-2
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
5 mg$98In Stock
10 mg$158In Stock
25 mg$286In Stock
50 mg$429In Stock
100 mg$596In Stock
200 mg$788In Stock
1 mL x 10 mM (in DMSO)$115In Stock
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Purity:99.3%
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Product Introduction

Bioactivity
Description
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
Targets&IC50
Raf:62 nM (BRAF V600E kinase assay), Raf:18 nM (Cell-Based Phosho-ERK Assay)
In vitro
The IC50 values of TBAP-001 are 178 nM (A375), 62 nM (WM266.4), 72 nM (UACC62), 93 nM (LOX INVI), 590 nM (HT 29), 43 nM (COLO225), 690 nM (RKO), 490 nM (Mawi), 390 nM (WiDr), 480 nM (Colo741), 480 nM (SW620), 600 nM (HCT116), 390 nM (SKMEL2), 710 nM (D04), 390 nM (WM1361), 1150 nM (PDAC R172H (p53 mut)), 290 nM (MiaPaCa) and 490nM (RPMI8226) in different cancer cell lines[1].
Chemical Properties
Molecular Weight531.51
FormulaC27H23F2N7O3
Cas No.1777832-90-2
SmilesCC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(F)c1
Relative Density.1.42 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (470.36 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8814 mL9.4072 mL18.8143 mL94.0716 mL
5 mM0.3763 mL1.8814 mL3.7629 mL18.8143 mL
10 mM0.1881 mL0.9407 mL1.8814 mL9.4072 mL
20 mM0.0941 mL0.4704 mL0.9407 mL4.7036 mL
50 mM0.0376 mL0.1881 mL0.3763 mL1.8814 mL
100 mM0.0188 mL0.0941 mL0.1881 mL0.9407 mL

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