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Lqvtdsglyrcviyhpp TFA

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Catalog No. T78026

LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].

Lqvtdsglyrcviyhpp TFA
Other Forms of Lqvtdsglyrcviyhpp TFA:
LQVTDSGLYRCVIYHPPT78025887255-16-5
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Lqvtdsglyrcviyhpp TFA

🥰Excellent
Purity: 95%
Catalog No. T78026
LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].
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1 mg$60In Stock
5 mg$147In Stock
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Purity:95%
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Product Introduction

Bioactivity
Description
LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].
In vitro
METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 or 10 μM) was used in microglia to investigate the function of TREM-1 in the microglial OGD model by real-time quantitative PCR.
RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA significantly reduced the mRNA levels of proinflammatory cytokines (NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, and iNOS) and chemokines (MCP-1, CXCL-1, and CXCL-2); microglia incubated with LQVTDSGLYRCVIYHPP (LP17) maximally preserved neuronal viability. [1]
In vivo
METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 mg/kg, intranasal) was used to confirm the biological function of TREM-1 in ischemic stroke.
RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA induced a significant decrease in TUNEL-positive cells and FJC-positive neurons. [1]
Chemical Properties
Molecular Weight2075.27
FormulaC91H138F3N23O27S
Smiles[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N5CCC[C@H]5C(O)=O)=O)=O)=O)=O)[C@@H](C)CC)=O)C(C)C)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)=O)CO)=O)=O)[C@H](O)C)=O)C(C)C)=O)CCC(N)=O)=O)CC(C)C.OC(C(F)(F)F)=O
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble)
DMSO: 80 mg/mL (38.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.4819 mL2.4093 mL4.8187 mL24.0933 mL
5 mM0.0964 mL0.4819 mL0.9637 mL4.8187 mL
10 mM0.0482 mL0.2409 mL0.4819 mL2.4093 mL
20 mM0.0241 mL0.1205 mL0.2409 mL1.2047 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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