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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
5 mg | $147 | In Stock |
Description | LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1]. |
In vitro | METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 or 10 μM) was used in microglia to investigate the function of TREM-1 in the microglial OGD model by real-time quantitative PCR. RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA significantly reduced the mRNA levels of proinflammatory cytokines (NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, and iNOS) and chemokines (MCP-1, CXCL-1, and CXCL-2); microglia incubated with LQVTDSGLYRCVIYHPP (LP17) maximally preserved neuronal viability. [1] |
In vivo | METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 mg/kg, intranasal) was used to confirm the biological function of TREM-1 in ischemic stroke. RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA induced a significant decrease in TUNEL-positive cells and FJC-positive neurons. [1] |
Molecular Weight | 2075.27 |
Formula | C91H138F3N23O27S |
Cas No. |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble) DMSO: 80 mg/mL (38.55 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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