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LQVTDSGLYRCVIYHPP

Name: LQVTDSGLYRCVIYHPP
Brand: TargetMol
SKU: T78025
Rating: 4.5 (1 reviews)

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Catalog No. T78025Cas No. 887255-16-5

LQVTDSGLYRCVIYHPP (LP17) is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that mitigates ischemia-induced infarction and neuronal damage. It can penetrate the brain and inhibit TREM-1 [1].

LQVTDSGLYRCVIYHPP

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Catalog No. T78025Cas No. 887255-16-5

Pack Size	Price	Availability
1 mg	$60	7-10 days
5 mg	$147	7-10 days
10 mg	$263	7-10 days
25 mg	$446	7-10 days
50 mg	$645	7-10 days
100 mg	$886	7-10 days
500 mg	$1,790	7-10 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	LQVTDSGLYRCVIYHPP (LP17) is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that mitigates ischemia-induced infarction and neuronal damage. It can penetrate the brain and inhibit TREM-1 [1].
In vitro	Treatment with LQVTDSGLYRCVIYHPP (LP17) at concentrations of 1 or 10 µM for 24 hours significantly reduced the mRNA levels of pro-inflammatory cytokines and chemokines following reoxygenation. Additionally, it notably decreased the extracellular protein levels of IL-1β and IL-18 in an oxygen-glucose deprivation (OGD) model of microglial cells [1]. At a concentration of 10 µM and the same duration, LP17 was found to interact with the SYK enzyme in microglial cells [1].
In vivo	LP17 (0.5 or 1 mg/kg; intranasal; once daily for 3 days) attenuated ischemia-induced infarction and neuronal damage in mice [1].

Chemical Properties

Molecular Weight	1961.24
Formula	C₈₉H₁₃₇N₂₃O₂₅S
Cas No.	887255-16-5

Storage & Solubility Information

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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