Shopping Cart
- Remove All
Your shopping cart is currently empty
Imeglimin
🥰Excellent
Catalog No. T22860Cas No. 775351-65-0
Alias RVT-1501, PXL 008, EMD-387008, EMD 387008
Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.
Imeglimin
🥰Excellent
Purity: 98.97%
Catalog No. T22860Alias RVT-1501, PXL 008, EMD-387008, EMD 387008Cas No. 775351-65-0
Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $127 | In Stock | |
| 25 mg | $237 | In Stock | |
| 50 mg | $383 | In Stock | |
| 100 mg | $563 | In Stock | |
| 500 mg | $1,180 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Imeglimin"
Acetylcysteine
Cited
N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC
T0875616-91-1
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
- $33
Size
QTY
CitedImeglimin hydrochloride
EMD 387008 hydrochloride
T7486775351-61-6
Imeglimin hydrochloride (EMD 387008 hydrochloride） is an oral hypoglycemic agent. Imeglimin improves insulin sensitivity, inhibits the production of reactive oxygen species, increases mitochondrial DNA, and improves mitochondrial function.
- $34
Size
QTY
Rotenone Cited
Rotocide, Rotenon, Paraderil, Dactinol, Barbasco
T297083-79-4
Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces apoptosis.
- $42
Size
QTY
CitedLycopene
ψ,ψ-Carotene
T2864502-65-8
Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As a class, carotenoids are pigment compounds found in photosynthetic organisms (plants, algae, and some types of fungus), and are chemically characterized by a large polyene chain containing 35-40 carbon atoms; some carotenoid polyene chains are terminated by two 6-carbon rings. In animals, carotenoids such as lycopene may possess antioxidant properties which may retard aging and many degenerative diseases. As an essential nutrient, lycopene is required in the animal diet.
- $50
Size
QTY
Ethyl cinnamate
TN1624103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl cinnamate can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 mM and 0.38 mM.
- $29
Size
QTY
Tempol
TMPN, Tanol, 4-Hydroxy-TEMPO
T66992226-96-2
Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
- $29
Size
QTY
Inosine Cited
NSC 20262, INO 495
T043758-63-9
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
- $29
Size
QTY
CitedD-Histidine
T9372351-50-8
D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.
- $37
Size
QTY
α-Lipoic Acid
Thioctic acid, DL-α-Lipoic acid, (±)-α-Lipoic acid
T02001077-28-7
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
- $29
Size
QTY
Boscalid
T36141188425-85-6
Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to 100% and ofS. sclerotiorumby 77 to 100% when used at a concentration of 1 μg/ml.2In field studies, boscalid applied at 5.6 μg/cm2provides 55.5 and 30.4% disease control for lettuce drop caused byS. minorandS. sclerotiorum, respectively. It decreases cell viability of mouse primary cortical neurons following long-term exposure but is not cytotoxic (LC50= >100 μM for acute and continuous exposure). Formulations containing boscalid have been used in agriculture to prevent fungal growth on crops.
1.Wang, Y., Duan, Y., Wang, J., et al.A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorumMol. Plant Pathol.16(7)653-661(2015) 2.Matheron, M.E., and Porchas, M.Activity of boscalid, fenhexamid, fluazinam, fludioxonil, and vinclozolin on growth of Sclerotinia minor and S. sclerotiorum and development of lettuce dropPlant Dis.88(6)665-668(2004)
- $35
Size
QTY
Nerol
Neryl alcohol, Cis-Geraniol
T5645106-25-2
Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
- $36
Size
QTY
Rifamycin S
T834713553-79-2
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
- $39
Size
QTY
Select Batch
Purity:98.97%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice. |
| In vitro | In Human endothelial cells (HMEC-1), Imeglimin (100 μM and 10 mM; 100 μM for 24 hours, 10 mM for 4 hours) can prevent cell death[2]. |
| In vivo | In 4-week-old male C57BL/6JOlaHsd mice, oral administration of Imeglimin (200 mg/kg; b.i.d.; for 6 weeks) caused a slight decrease in body weight and food intake, associated with some diarrhea, but these effects were only observed during the first few days of treatment[1]. |
| Alias | RVT-1501, PXL 008, EMD-387008, EMD 387008 |
| Molecular Weight | 155.2 |
| Formula | C6H13N5 |
| Cas No. | 775351-65-0 |
| Smiles | Cl.C[C@@H]1N=C(N)NC(=N1)N(C)C |
| Relative Density. | 1.29 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Imeglimin | purchase Imeglimin | Imeglimin cost | order Imeglimin | Imeglimin chemical structure | Imeglimin in vivo | Imeglimin in vitro | Imeglimin formula | Imeglimin molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.