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Tempol

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Purity:99.74%

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COA LCMS

Tempol

Catalog No. T6699Cas No. 2226-96-2

Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.

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Pack Size	Price	Availability	Quantity
500 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Product Introduction

Bioactivity

Description	Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
In vitro	Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2]
In vivo	Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6]
Cell Research	The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference)
Alias	TMPN, Tanol, 4-Hydroxy-TEMPO

Chemical Properties

Molecular Weight	172.25
Formula	C9H18NO2
Cas No.	2226-96-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/mL (580.59 mM ), Sonication is recommended.

Ethanol: 17.2 mg/mL (100 mM)

DMSO: 55 mg/mL (319.32 mM)

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.8055 mL	29.0276 mL	58.0552 mL	290.2758 mL
5 mM	1.1611 mL	5.8055 mL	11.6110 mL	58.0552 mL
10 mM	0.5806 mL	2.9028 mL	5.8055 mL	29.0276 mL
20 mM	0.2903 mL	1.4514 mL	2.9028 mL	14.5138 mL
50 mM	0.1161 mL	0.5806 mL	1.1611 mL	5.8055 mL
100 mM	0.0581 mL	0.2903 mL	0.5806 mL	2.9028 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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