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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $29 | In Stock | |
1 mL x 10 mM (in DMSO) | $32 | In Stock |
Description | Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects. |
In vitro | Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
In vivo | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
Cell Research | The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference) |
Alias | TMPN, Tanol, 4-Hydroxy-TEMPO |
Molecular Weight | 172.25 |
Formula | C9H18NO2 |
Cas No. | 2226-96-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (580.59 mM ), Sonication is recommended. ![]() Ethanol: 17.2 mg/mL (100 mM) DMSO: 55 mg/mL (319.32 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
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