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Glucagon (1-29), bovine, human, porcine hydrochloride
Catalog No. T15389LCas No. 28270-04-4
Alias Porcine glucagon hydrochloride, Glucagon hydrochloride
Glucagon (1-29), bovine, human, porcine hydrochloride (Porcine glucagon hydrochloride) is a peptide hormone produced by pancreatic α-cells that activates HNF4α, increases HNF4α phosphorylation, and stimulates gluconeogenesis.
Glucagon (1-29), bovine, human, porcine hydrochloride
Catalog No. T15389LAlias Porcine glucagon hydrochloride, Glucagon hydrochlorideCas No. 28270-04-4
Glucagon (1-29), bovine, human, porcine hydrochloride (Porcine glucagon hydrochloride) is a peptide hormone produced by pancreatic α-cells that activates HNF4α, increases HNF4α phosphorylation, and stimulates gluconeogenesis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $79 | In Stock | |
| 5 mg | $193 | In Stock | |
| 10 mg | $289 | In Stock | |
| 25 mg | $498 | In Stock | |
| 50 mg | $729 | In Stock | |
| 100 mg | $985 | In Stock | |
| 500 mg | $1,970 | In Stock |
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Purity:98.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Glucagon (1-29), bovine, human, porcine hydrochloride (Porcine glucagon hydrochloride) is a peptide hormone produced by pancreatic α-cells that activates HNF4α, increases HNF4α phosphorylation, and stimulates gluconeogenesis. |
| In vitro | Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon (100 nM) increases the phosphorylation of HNF4α. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes [3]. |
| In vivo | Glucagon (20 μg/kg) increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice [4]. |
| Alias | Porcine glucagon hydrochloride, Glucagon hydrochloride |
| Molecular Weight | 3519.21 |
| Formula | C153H225N43O49S.ClH |
| Cas No. | 28270-04-4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM H2O: 40 mg/mL (11.37 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
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