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Glucagon (1-29), bovine, human, porcine

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Catalog No. T15389Cas No. 16941-32-5
Alias Glucagon

Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.

Glucagon (1-29), bovine, human, porcine
Other Forms of Glucagon (1-29), bovine, human, porcine:

Glucagon (1-29), bovine, human, porcine

😃Good
Purity: 99.56%
Catalog No. T15389Alias GlucagonCas No. 16941-32-5
Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.
Pack SizePriceAvailabilityQuantity
1 mg$667-10 days
5 mg$198In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.
In vitro
Glucagon (1-29), bovine, human, porcine binds to its receptor Gcgr and activates the cAMP-PKA signaling pathway, which in turn promotes hepatic gluconeogenesis and triggers hyperglycemia. In addition, Glucagon (1-29), bovine, human, porcine stimulates hepatic production of kisspeptin1 and gluconeogenesis. [1]
Glucagon (1-29), bovine, human, porcine inhibits the expression of CYP7A1 mRNA in human primary hepatocytes at a concentration of 100 nM and increases the phosphorylation of HNF4α. increased the phosphorylation level of HNF4α. [3]
In vivo
A low dose of 20 μg/kg Glucagon (1-29), bovine, human, porcine increased blood glucose but did not stimulate insulin secretion in mice fed in a normal environment. A high dose of 1 mg/kg Glucagon (1-29), bovine, human, porcine lowered blood glucose and stimulated insulin secretion in mice fed in a normal environment compared to the PBS control. [4]
AliasGlucagon
Chemical Properties
Molecular Weight3482.75
FormulaC153H225N43O49S
Cas No.16941-32-5
SmilesC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CN=CN5)N)=O)CO)=O)CCC(N)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CCCCN)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)[C@H](C)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CC(N)=O)=O)CCSC)=O)CC(C)C)=O)C=6C=7C(NC6)=CC=CC7
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1 mg/mL (0.29 mM), Sonication is recommended.
H2O: 4 mg/mL (1.15 mM), Adjust pH to 2 with HCl and sonication is recommended.)

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Keywords

Porcine glucagon(1-29), bovine, human, porcineGlucagonReceptorGlucagon ReceptorGlucagon , bovine, human, porcineGlucagon (129), bovine, human, porcineGlucagon (1 29), bovine, human, porcine
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