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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $56 | 7-10 days | |
5 mg | $162 | 7-10 days | |
10 mg | $250 | 7-10 days | |
25 mg | $486 | 7-10 days | |
50 mg | $654 | 7-10 days | |
100 mg | Inquiry | 7-10 days | |
200 mg | Inquiry | 7-10 days |
Description | Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. |
In vitro | Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3]. |
In vivo | Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4]. |
Alias | Porcine glucagon, Glucagon |
Molecular Weight | 3482.75 |
Formula | C153H225N43O49S |
Cas No. | 16941-32-5 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (14.36 mM) H2O: 20 mg/mL (5.74 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
|
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