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Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,309 | 6-8 weeks | |
25 mg | Inquiry | 6-8 weeks | |
50 mg | Inquiry | 6-8 weeks | |
100 mg | Inquiry | 6-8 weeks |
Description | Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes. |
In vitro | Lupanine (0-100 μM) treats SH-SY5Y cells with EC50 and DC50 values of 10.7 μM and 28.2 μM, respectively. [2] |
In vivo | Methods: Lupanine (20 mg/kg, orally) was administered to non-diabetic and diabetic rats, and an oral glucose tolerance test was performed 30 minutes later. Results: Lupanine reduced blood glucose concentrations and improved glycemic control in an in vivo diabetic rat model. [3] |
Alias | D-Lupanine, (+)-Lupanine |
Molecular Weight | 248.36 |
Formula | C15H24N2O |
Cas No. | 550-90-3 |
Smiles | O=C1N2[C@@]([C@]3(C[C@@](C2)([C@]4(N(C3)CCCC4)[H])[H])[H])(CCC1)[H] |
Relative Density. | 1.16g/cm3 |
Storage | keep away from direct sunlight | store at 4°C | Shipping with blue ice. |
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