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Lupanine

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Catalog No. TMA0805Cas No. 550-90-3
Alias D-Lupanine, (+)-Lupanine

Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.

Lupanine

Lupanine

😃Good
Catalog No. TMA0805Alias D-Lupanine, (+)-LupanineCas No. 550-90-3
Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
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5 mg$1,309 6-8 weeks
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50 mgInquiry6-8 weeks
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Product Introduction

Bioactivity
Description
Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
In vitro
Lupanine (0-100 μM) treats SH-SY5Y cells with EC50 and DC50 values ​​of 10.7 μM and 28.2 μM, respectively. [2]
In vivo
Methods: Lupanine (20 mg/kg, orally) was administered to non-diabetic and diabetic rats, and an oral glucose tolerance test was performed 30 minutes later.
Results: Lupanine reduced blood glucose concentrations and improved glycemic control in an in vivo diabetic rat model. [3]
AliasD-Lupanine, (+)-Lupanine
Chemical Properties
Molecular Weight248.36
FormulaC15H24N2O
Cas No.550-90-3
SmilesO=C1N2[C@@]([C@]3(C[C@@](C2)([C@]4(N(C3)CCCC4)[H])[H])[H])(CCC1)[H]
Relative Density.1.16g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | store at 4°C | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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