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Mahanimbine

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Catalog No. T15949Cas No. 21104-28-9

Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats.

Mahanimbine

Mahanimbine

😃Good
Catalog No. T15949Cas No. 21104-28-9
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats.
Pack SizePriceAvailabilityQuantity
1 mg$17035 days
5 mg$75535 days
10 mg$1,33035 days
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Product Introduction

Bioactivity
Description
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats.
Targets&IC50
Capan-2 cells:3.5 µM, SW1190 cells:3.5 µM, HPAF-II cells:32 µM, BxPC-3 cells:16 µM, S. aureus:50 µg/ml(MIC100), CFPAC-1 cells:64 µM
In vitro
Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).[2]
It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.[3]
In vivo
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin-responsive genes in the liver and adipose tissue. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine (2-4 mg/kg ; p.o. ; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).[1]
Chemical Properties
Molecular Weight331.45
FormulaC23H25NO
Cas No.21104-28-9
SmilesCC1=C2C(=C3C(C=4C(N3)=CC=CC4)=C1)C=C[C@@](CCC=C(C)C)(C)O2
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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