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FX-11
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
Catalog No. T15362Cas No. 213971-34-7
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Purity:98.95%
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FX-11
Catalog No. T15362Alias LDHA Inhibitor FX11Cas No. 213971-34-7
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | Inquiry | In Stock | |
| 50 mg | Inquiry | 14-16 weeks | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer. |
| Targets&IC50 | LDHA (HeLa cells):23.3 μM, LDHA:8 μM(Ki), LDHA (HeLa cells):23.3 μM, DU145 cells:32 ± 1.1 μM, PC3 cells:27 ± 1.1 μM |
| In vitro | FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1] FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2] |
| In vivo | FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1] FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2] |
| Alias | LDHA Inhibitor FX11 |
| Molecular Weight | 350.41 |
| Formula | C22H22O4 |
| Cas No. | 213971-34-7 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (642.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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