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Ivosidenib

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.

Catalog No. T3617Cas No. 1448347-49-6

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Purity:100%

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COA HPLC HNMR

Ivosidenib

Catalog No. T3617Cas No. 1448347-49-6

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$42	In Stock
5 mg	$66	In Stock
10 mg	$123	In Stock
25 mg	$196	In Stock
50 mg	$315	In Stock
100 mg	$509	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock

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Product Introduction

Bioactivity

Description	Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Targets&IC50	IDH1 (R132H):12 nM
In vitro	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1].
Cell Research	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)
Alias	AG-120

Chemical Properties

Molecular Weight	582.96
Formula	C₂₈H₂₂ClF₃N₆O₃
Cas No.	1448347-49-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 100 mg/mL (171.54 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (85.77 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.7154 mL	8.5769 mL	17.1538 mL	85.7692 mL
5 mM	0.3431 mL	1.7154 mL	3.4308 mL	17.1538 mL
10 mM	0.1715 mL	0.8577 mL	1.7154 mL	8.5769 mL
20 mM	0.0858 mL	0.4288 mL	0.8577 mL	4.2885 mL
50 mM	0.0343 mL	0.1715 mL	0.3431 mL	1.7154 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0172 mL	0.0858 mL	0.1715 mL	0.8577 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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