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PARP/PI3K-IN-1

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Purity:99.59%

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COA HPLC HNMR

PARP/PI3K-IN-1

Catalog No. T12365Cas No. 2337386-47-5

PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.

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Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$413	In Stock
10 mg	$662	In Stock
25 mg	$1,320	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock

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Product Introduction

Bioactivity

Description	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
In vitro	PARP/PI3K-IN-1 (1 μM; 72 h) decreased the levels of self-phosphorylation of AKT and S6, while increasing the phosphorylation levels of ERK following treatment, indicating the inhibition of the PI3K pathway and activation of the ERK pathway by PARP/PI3K-IN-1, resulting in significantly increased apoptosis.[1]. In BRCA-deficient cells, PARP/PI3K-IN-1 not only exhibits significant inhibitory activity against HCC1937 and HCT116, but also demonstrates anti-proliferative activity against MDA-MB-231 and MDA-MB-468 [1].
In vivo	PARP/PI3K-IN-1 (IP; 50 mg/kg; treatment for 34 days) significantly inhibits tumor growth[1].

Chemical Properties

Molecular Weight	660.62
Formula	C33H28F4N8O3
Cas No.	2337386-47-5

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (121.10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5137 mL	7.5686 mL	15.1373 mL	75.6865 mL
5 mM	0.3027 mL	1.5137 mL	3.0275 mL	15.1373 mL
10 mM	0.1514 mL	0.7569 mL	1.5137 mL	7.5686 mL
20 mM	0.0757 mL	0.3784 mL	0.7569 mL	3.7843 mL
50 mM	0.0303 mL	0.1514 mL	0.3027 mL	1.5137 mL
100 mM	0.0151 mL	0.0757 mL	0.1514 mL	0.7569 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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