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MMRi62

🥰Excellent
Catalog No. T60202Cas No. 352693-80-2
Alias 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

MMRi62

MMRi62

🥰Excellent
Purity: 99.7%
Catalog No. T60202Alias 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-olCas No. 352693-80-2
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$64In Stock
10 mg$106In Stock
25 mg$213In Stock
50 mg$347In Stock
100 mg$553In Stock
500 mg$1,180In Stock
1 mL x 10 mM (in DMSO)$71In Stock
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Purity:99.7%
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Product Introduction

Bioactivity
Description
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
In vitro
MMRi62 inhibits the proliferation, cloning and spherical growth of pancreatic ductal adenocarcinoma cells (PDAC) by inducing cell death [1]. MMRi62 (3 nM-100 μ M; 4 h) Combined with the ring heterodimer of MDM2 and MDM4, Kd value is 1.39 μ M. MMRi62 (10 nM-1 μ M; 72 h) to induce apoptosis of leukemia cells, and the IC50 to inhibit leukemia cells are 0.34 respectively μ M (HL60) and 0.22 μ M (HL60VR). MMRi62 (5 μ M, 10 μ M; 24 h) Reduce the autoubiquitination of MDM2B and increase the ubiquitination of MDM4 in a dose dependent manner. MMRi62 is an E3 ligase modifier that can switch substrate preference from MDM2 to MDM4. MMRi62 (5 μ M; 24, 72 h) induced apoptosis, independent of p53 [2].
In vivo
MMRi62 showed anti-tumor activity in the orthotopic xenotransplantation PDAC mouse model by inhibiting the down-regulation of NCOA4 and mutant p53 to inhibit tumor growth in mice. MMRi62 also completely eliminates metastasis of tumors in situ [1].
Alias7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
Chemical Properties
Molecular Weight396.27
FormulaC21H15Cl2N3O
Cas No.352693-80-2
SmilesOc1c(ccc2cccnc12)C(Nc1ccccn1)c1cccc(Cl)c1Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (126.18 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5235 mL12.6177 mL25.2353 mL126.1766 mL
5 mM0.5047 mL2.5235 mL5.0471 mL25.2353 mL
10 mM0.2524 mL1.2618 mL2.5235 mL12.6177 mL
20 mM0.1262 mL0.6309 mL1.2618 mL6.3088 mL
50 mM0.0505 mL0.2524 mL0.5047 mL2.5235 mL
100 mM0.0252 mL0.1262 mL0.2524 mL1.2618 mL

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