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NSC305787

NSC305787
NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity.
Catalog No. T12263Cas No. 785718-37-8

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NSC305787

Catalog No. T12263Cas No. 785718-37-8

NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$3476-8 weeks
25 mg$1,1406-8 weeks
50 mg$1,4906-8 weeks
100 mg$1,9906-8 weeks
1 mL x 10 mM (in DMSO)$3826-8 weeks
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Product Introduction

Bioactivity
Description
NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity.
Targets&IC50
Ezrin:5.85 μM (kd), Ezrin:8.3 μM
In vivo
NSC305787 mimicked the ezrin morpholino phenotype, and NSC668394 caused a unique developmental defect consistent with reduced cell motility in zebrafish.?Following tail vein injection of OS cells into mice, both molecules inhibited lung metastasis of ezrin-sensitive cells, but not ezrin-resistant cells.?The small molecule inhibitors NSC305787 and NSC668394 demonstrate a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis[1].
Chemical Properties
Molecular Weight445.42
FormulaC25H30Cl2N2O
Cas No.785718-37-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6 mg/mL (13.47 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2451 mL11.2254 mL22.4507 mL112.2536 mL
5 mM0.4490 mL2.2451 mL4.4901 mL22.4507 mL
10 mM0.2245 mL1.1225 mL2.2451 mL11.2254 mL

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