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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $347 | 6-8 weeks | |
25 mg | $1,140 | 6-8 weeks | |
50 mg | $1,490 | 6-8 weeks | |
100 mg | $1,990 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $382 | 6-8 weeks |
Description | NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity. |
Targets&IC50 | Ezrin:5.85 μM (kd), Ezrin:8.3 μM |
In vivo | NSC305787 mimicked the ezrin morpholino phenotype, and NSC668394 caused a unique developmental defect consistent with reduced cell motility in zebrafish.?Following tail vein injection of OS cells into mice, both molecules inhibited lung metastasis of ezrin-sensitive cells, but not ezrin-resistant cells.?The small molecule inhibitors NSC305787 and NSC668394 demonstrate a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis[1]. |
Molecular Weight | 445.42 |
Formula | C25H30Cl2N2O |
Cas No. | 785718-37-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 6 mg/mL (13.47 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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