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SIRT6-IN-3
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Catalog No. T79689Cas No. 3023471-40-8
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
SIRT6-IN-3
😃Good
Catalog No. T79689Cas No. 3023471-40-8
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1]. |
| Targets&IC50 | HDAC8:102 μM, SIRT1:80.52 μM, HDAC6:96.77 μM, SIRT6:7.46 μM, HDAC3:111.9 μM, SIRT2:92.21 μM |
| In vitro | SIRT6-IN-3 at a concentration of 25 μM induces a cell cycle arrest and apoptosis in PDAC cells after 48 hours of treatment [1]. When applied for 72 hours, SIRT6-IN-3 continues to hinder the proliferation of pancreatic cancer cells by inhibiting cellular signaling pathways [1]. |
| In vivo | SIRT6-IN-3 exhibits antitumor effects in a murine tumor model [1]. When used in combination with gemcitabine (at a ratio of 2:1), SIRT6-IN-3 enhances the anticancer activity of gemcitabine [1]. |
| Molecular Weight | 673.73 |
| Formula | C21H30Br3ClN6S |
| Cas No. | 3023471-40-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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