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JGB1741

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Purity:97.24%

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COA HPLC HNMR

JGB1741

Catalog No. T22094Cas No. 1256375-38-8

JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.

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Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$178	In Stock
10 mg	$297	In Stock
25 mg	$523	In Stock
50 mg	$759	In Stock
100 mg	$1,060	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock

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Product Introduction

Bioactivity

Description	JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.
In vitro	JGB1741 (1-10000 nM) inhibits the cell proliferation of K562, HepG2 and MDA-MB 231 cell lines. JGB1741 (0.01-1 μM) induces apoptosis of MDA-MB 231 and shows a cell cycle arrest at G1 phase with more cells entering into sub G0/G1 phase. JGB1741 (0.01-1 μM) increases the global acetylation of H3K9, acetylated p53K382 levels and p53 expression[1].
Alias	ILS-JGB-1741

Chemical Properties

Molecular Weight	440.56
Formula	C27H24N2O2S
Cas No.	1256375-38-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 4.41 mg/mL (10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2698 mL	11.3492 mL	22.6984 mL	113.4919 mL
5 mM	0.4540 mL	2.2698 mL	4.5397 mL	22.6984 mL
10 mM	0.2270 mL	1.1349 mL	2.2698 mL	11.3492 mL

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