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JGB1741

Catalog No. T22094   CAS 1256375-38-8
Synonyms: ILS-JGB-1741

JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
JGB1741 Chemical Structure
JGB1741, CAS 1256375-38-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 178.00
10 mg In stock $ 297.00
25 mg In stock $ 523.00
50 mg In stock $ 759.00
100 mg In stock $ 1,060.00
1 mL * 10 mM (in DMSO) In stock $ 213.00
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Purity: 97.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.
In vitro JGB1741 (1-10000 nM) inhibits the cell proliferation of K562, HepG2 and MDA-MB 231 cell lines. JGB1741 (0.01-1 μM) induces apoptosis of MDA-MB 231 and shows a cell cycle arrest at G1 phase with more cells entering into sub G0/G1 phase. JGB1741 (0.01-1 μM) increases the global acetylation of H3K9, acetylated p53K382 levels and p53 expression[1].
Synonyms ILS-JGB-1741
Molecular Weight 440.56
Formula C27H24N2O2S
CAS No. 1256375-38-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.41 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library DNA Damage & Repair Compound Library Inhibitor Library Epigenetics Compound Library Histone Modification Compound Library

Related Products

Related compounds with same targets
SRT3657 B2 Scopolin Ginkgolide C Cambinol Nicotinamide riboside chloride SRT 1460 SIRT7 inhibitor 97491

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Keywords

JGB1741 1256375-38-8 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin ILS-JGB 1741 ILS-JGB-1741 JGB 1741 ILS-JGB1741 JGB-1741 inhibitor inhibit

 

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