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EAD1 TFA(1644388-26-0 Free base)
EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis
Catalog No. T35329LCas No. 2320427-95-8
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Purity:97.49%
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EAD1 TFA(1644388-26-0 Free base)
Catalog No. T35329LCas No. 2320427-95-8
EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 2 mg | $85 | In Stock | |
| 5 mg | $157 | In Stock | |
| 10 mg | $233 | In Stock | |
| 25 mg | $382 | In Stock | |
| 50 mg | $529 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $195 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis |
| Targets&IC50 | Autophagy (BxPC3 cells):5.8 μM |
| In vitro | EAD1 HCL (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines. EAD1 HCL (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner. EAD1 HCL (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells[1]. |
| Alias | EAD1 HCL(1644388-26-0 Free base) |
| Molecular Weight | 598.45 |
| Formula | C26H28Cl2F3N7O2 |
| Cas No. | 2320427-95-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (105.59 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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