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Gunagratinib

Catalog No. T39682   CAS 2211082-53-8
Synonyms: ICP-192

Gunagratinib (ICP-192) is a potent and selective, orally active pan-FGFR (fibroblast growth factor receptors) inhibitor with low toxicity, exhibiting irreversible covalent binding to effectively inhibit FGFR activities. It is particularly suitable for cancer research purposes.

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Gunagratinib Chemical Structure
Gunagratinib, CAS 2211082-53-8
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gunagratinib (ICP-192) is a potent and selective, orally active pan-FGFR (fibroblast growth factor receptors) inhibitor with low toxicity, exhibiting irreversible covalent binding to effectively inhibit FGFR activities. It is particularly suitable for cancer research purposes.
In vitro Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding[1].
Synonyms ICP-192
Molecular Weight 423.473
Formula C22H25N5O4
CAS No. 2211082-53-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Guo Ye, et al. Phase I result of ICP-192 (gunagratinib), a highly selective irreversible FGFR inhibitor, in patients with advanced solid tumors harboring FGFR pathway alterations. Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021) 4092-4092.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gunagratinib 2211082-53-8 ICP192 ICP 192 ICP-192 inhibitor inhibit

 

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