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Opnurasib

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Purity:98.88%

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COA HPLC HNMR

Opnurasib

Catalog No. T40292Cas No. 2653994-08-0

Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer.

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Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$372	In Stock
10 mg	$555	In Stock
25 mg	$893	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$428	In Stock

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Product Introduction

Bioactivity

Description	Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell lung cancer.
In vitro	Opnurasib selectively forms a covalent bond with and inhibits GDP-bound KRASG12C, demonstrating a low reversible binding affinity to the RAS switch II pocket. Additionally, it effectively hinders the proliferation of cell lines carrying KRASG12C mutations, as well as those with double mutations G12C/H95, G12C/R68S, and G12C/Y96.[2] Opnurasib induces dose-dependent decreases in phosphorylated ERK (pERK) levels and inhibits the proliferation of KRASG12C-mutated cell lines NCI-H358 and NCI-H2122, exhibiting IC50 values of 0.018 and 0.063 μM, respectively.[2]
In vivo	Opnurasib elicits distinct antitumor responses in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal tumors, and these responses are further enhanced when Opnurasib is used in combination with other therapeutic agents.[2]
Alias	NVP-JDQ443, JDQ-443, Opnurasib

Chemical Properties

Molecular Weight	526.03
Formula	C29H28ClN7O
Cas No.	2653994-08-0

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (133.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9010 mL	9.5052 mL	19.0103 mL	95.0516 mL
5 mM	0.3802 mL	1.9010 mL	3.8021 mL	19.0103 mL
10 mM	0.1901 mL	0.9505 mL	1.9010 mL	9.5052 mL
20 mM	0.0951 mL	0.4753 mL	0.9505 mL	4.7526 mL
50 mM	0.0380 mL	0.1901 mL	0.3802 mL	1.9010 mL
100 mM	0.0190 mL	0.0951 mL	0.1901 mL	0.9505 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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