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GSTO1-IN-1

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Purity:98.45%

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COA HNMR HPLC

GSTO1-IN-1

Catalog No. T11505Cas No. 568544-03-6

GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1) with an IC50 of 31 nM.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$77	In Stock
10 mg	$122	In Stock
50 mg	$178	In Stock
100 mg	$313	In Stock
200 mg	$468	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Product Introduction

Bioactivity

Description	GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1) with an IC50 of 31 nM.
Targets&IC50	GSTO1:31 nM
In vitro	GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to the recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner.
In vivo	GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study.

Chemical Properties

Molecular Weight	311.18
Formula	C10H12Cl2N2O3S
Cas No.	568544-03-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 300 mg/mL (964.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2136 mL	16.0679 mL	32.1357 mL	160.6787 mL
5 mM	0.6427 mL	3.2136 mL	6.4271 mL	32.1357 mL
10 mM	0.3214 mL	1.6068 mL	3.2136 mL	16.0679 mL
20 mM	0.1607 mL	0.8034 mL	1.6068 mL	8.0339 mL
50 mM	0.0643 mL	0.3214 mL	0.6427 mL	3.2136 mL
100 mM	0.0321 mL	0.1607 mL	0.3214 mL	1.6068 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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